In the lab, we coupled different imaging, data analysis and nanoscale fabrication technologies to study biological processes in T cells, which are white blood cells that scan our body for molecular signals of ‘danger’ activating an immune response when they recognise one. We want to learn how T-cells come to a decision of activating, which mechanisms are in place to prevent aberrant activation, and whether the cell membrane plays a role in modulating these responses. 

Most recently, in the imaging section, we used multi-colour, single-molecule super-resolution microscopy (DNA-qPAINT) and quantitative image analysis techniques to understand how nanoscale clustering of the primary inhibitor protein in T cells, Csk, regulates T cell receptor signalling activation.


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